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Summary Skeletal Muscle Chapter 14

Course
- Training Aging and Disuse
- Richard Jaspers
- 2017 - 2018
- VU
- _TEACHER_GENERAL_
56 Flashcards & Notes
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A snapshot of the summary - Skeletal Muscle Chapter 14

  • 1 Embryonic origins and fetal development

  • From which embryonic cell layer are skeletal muscles cells derived?
    The embryonic mesodermal layer
  • What are the precursors of satelite cells?
    myoblasts that retain mitotic potential.
  • Name the order of development of a muscle cell from stem cell to myofiber.
    • mesodermal stem cell
    • myoblast
    • primary myotube
    • secondary myotube
    • myofiber
  • What is special about the connection between primary and secondary myotubes?
    They share the same basement membrane, until further development seperates the tubes by personal membranes.
  • The soleus has mainly slow twitch fibers, what is thought about the origin of the soleus myofibers?
    They probably originate from primary myotubes.
  • When during the gestation period are the first contractile elements formed?
    Around the ninth week of gestation.
  • Which factors initiate the transition from myoblasts to myotubes?
    myf genes like myf5, myoD, MRF4 and myogenin
  • Which factor inhibits the transition from myoblast to myotube?
    Myostatin, it inhibits the function of myoD
  • When during the gestation do myotubes start to proliferate?
    From 11 weeks onward
  • When during the gestation do tertiary myotubes occur?
    Around the 16th week.
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