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A snapshot of the summary - Skeletal Muscle Chapter 14
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1 Embryonic origins and fetal development
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From which embryonic cell layer are skeletal muscles cells derived?The embryonic mesodermal layer
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What are the precursors of satelite cells?myoblasts that retain mitotic potential.
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Name the order of development of a muscle cell from stem cell to myofiber.
- mesodermal stem cell
- myoblast
- primary myotube
- secondary myotube
- myofiber
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What is special about the connection between primary and secondary myotubes?They share the same basement membrane, until further development seperates the tubes by personal membranes.
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The soleus has mainly slow twitch fibers, what is thought about the origin of the soleus myofibers?They probably originate from primary myotubes.
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When during the gestation period are the first contractile elements formed?Around the ninth week of gestation.
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Which factors initiate the transition from myoblasts to myotubes?myf genes like myf5, myoD, MRF4 and myogenin
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Which factor inhibits the transition from myoblast to myotube?Myostatin, it inhibits the function of myoD
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When during the gestation do myotubes start to proliferate?From 11 weeks onward
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When during the gestation do tertiary myotubes occur?Around the 16th week.
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