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Summary: Tumorbio-10
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1 Tumorbio-10
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What is the function of histonmodification?
deacetylation and methylation; inactivation chromatide -> histonen wound up to tight (H3K27MES) -
What is DNA hypomethylation?
general loss of methylation -> dedifferentiation + genomic instability -
What is DNA hypermethylation?
to much methylation -> inactivation of TSG -
What kind of epigenetic changes are present in CRC?
DNA hypomethylation + K-RAS mutation -
What happens if tumor suppressor genes get inactivation?
1) mutation and LOH
2) gene silencing (de novo CpG methylation) -
How does the p15 pathway INK4?
block CDK4/6 -> RbhypoP (alleen in hematologische tumoren) -
How does the p14 ARF pathway?
block MDM2 - >cell cycle arrest -> p53/p21 (in gastro-intenstional tumors) -
How does the P16 INK4a pathway?
CDK4/6 -> RbhypoP -> solid tumors zoals borst, long, pancreas enzo -
What is the function of leukemia fusion proteins in epigen. deregulation?
(AML-ETO, PMLRARalfa) recruitment transcription co-repressor complexes met NCOR1/2 -> loss of histone acetylation and acquisition marks as H3K9 -> transcription silencing for crucial haematopoetic differntaition genes -
What does miRNA regulate in cancerogenesis?
1) cel proliferation in cancer
2) apoptosis in cancer
3) limitless replicative potential of ,,
4) angiogenesis of ,,
5) immune response of ,,
6) tumor invasion and metastasis of ,,
7) genomic instability of ,,
8) metabolism of ,,
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