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T cell function and the destruction of cell-associated invaders

Q: Cytotoxic T cell subsets

- Unlike helper cells that easily differentiate into TH1 or 2 cells CD8 T cells prefer the Tc1 phenotype

Q: Other mechanisms of cellular cytotoxicity

- CD8 are not the only ones that can kill cells - Cells with antibody receptors Fc-gamma-R1 of 2 can also kill other cells

Q: Classical macrophage activation

- Classical macrophages become fully activated in two stages - Exposure to bacteria triggers initial activation - Exposure to IFN-gamma triggers complete acitvation

Q: Alternative macrophage activation

- Macrophages activated through Fc-gamma-R or Th2 become M2 cells (anti inflammatory) - M2 cells promote Th2 and tissue repair

Q: Effector T cell memory

- The effector phase of T cells is short - Most of the generated CD8 cells die after infection - Cells that survive become memory cells - are CD44 -> express increased amounts of adhesion molecules

5 important questions on T cell function and the destruction of cell-associated invaders

Cytotoxic T cell subsets

- Unlike helper cells that easily differentiate into TH1 or 2 cells CD8 T cells prefer the Tc1 phenotype

Other mechanisms of cellular cytotoxicity

- CD8 are not the only ones that can kill cells
- Cells with antibody receptors Fc-gamma-R1 of 2 can also kill other cells

Classical macrophage activation

- Classical macrophages become fully activated in two stages
- Exposure to bacteria triggers initial activation
- Exposure to IFN-gamma triggers complete acitvation

Alternative macrophage activation

- Macrophages activated through Fc-gamma-R or Th2 become M2 cells (anti inflammatory)
- M2 cells promote Th2 and tissue repair

Effector T cell memory

- The effector phase of T cells is short
- Most of the generated CD8 cells die after infection
- Cells that survive become memory cells
- are CD44 -> express increased amounts of adhesion molecules